If you get any of these, stop using the medicine and get medical help at once. Talk to a doctor as soon as possible If you have acute dysentery , the symptoms of which may include blood in your stools and a high temperature.

If your doctor has prescribed loperamide for you or your child, follow their instructions about how and when to take it. How to take it This medicine contains less than 0.00003 mg of alcohol (ethanol) in each tablet. The small amount of alcohol in this Consult your doctor if you develop new symptoms, if your symptoms worsen, or your symptoms have not improved over two weeks.Bullous eruption a (including Stevens-Johnson syndrome, Toxic epidermal necrolysis and Erythema multiforme)

If you have acute dysentery, the symptoms of which may include blood in your stools and a high temperature. see section 3). Serious heart problems (symptoms of which include fast or irregular heartbeat) have been reported in patients who have taken too much loperamide, the active ingredient in IMODIUM® Instant Melts. If a doctor prescribes loperamide for your child, they will use their weight or age to work out the right dose. The dose also depends on their symptoms. What if I forget to take it?You can also report side effects directly via the Yellow Card Scheme at: or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine. In individuals who have ingested overdoses of loperamide, cardiac events such as QT interval and QRS complex prolongation, torsades de pointes, other serious ventricular arrhythmias, cardiac arrest and syncope have been observed (see section 4.4). Fatal cases have also been reported. Overdose can unmask existing Brugada syndrome. Non-clinical data have shown that loperamide is a P-glycoprotein substrate. Concomitant administration of loperamide (16 mg single dose) with quinidine, or ritonavir, which are both P-glycoprotein inhibitors, resulted in a 2 to 3-fold increase in loperamide plasma levels. The clinical relevance of this pharmacokinetic interaction with P-glycoprotein inhibitors, when loperamide is given at recommended dosages is unknown. Children react more strongly to large amounts of IMODIUM® Instant Melts than adults. If a child takes too much or shows any of the above symptoms, call a doctor immediately. If you forget to take the medicine If you miss a dose of loperamide, do not worry. Just take a dose after you next go to the toilet and have a runny poo.

You should only take this medicine as you need it, following the dosage instructions above carefully.headaches – make sure you rest and drink plenty of fluids. Do not drink too much alcohol. Ask your pharmacist to recommend a painkiller. Talk to your doctor if the headaches last longer than a week or are severe.

If you are breast-feeding do not take this medicine. Small amounts may get into your milk. Talk to your doctor about a suitable treatment. a: Inclusion of this term is based on post-marketing reports for loperamide HCl. As the process for determining post marketing ADRs did not differentiate between chronic and acute indications or adults and children, the frequency is estimated from all clinical trials with loperamide HCl (acute and chronic), including trials in children ≤ 12 years (N=3683). You can also report side effects directly via the Yellow Card Scheme at: or search for MHRA Yellow Card in the Google Play or Apple App Store.

Metabolism: loperamide is almost completely extracted by the liver, where it is predominantly metabolized, conjugated and excreted via the bile. Oxidative N-demethylation is the main metabolic pathway for loperamide, and is mediated mainly through CYP3A4 and CYP2C8. Due to this very high first pass effect, plasma concentrations of unchanged drug remain extremely low. The concomitant administration of loperamide (4 mg single dose) and itraconazole, an inhibitor of CYP3A4 and P-glycoprotein, resulted in a 3 to 4-fold increase in loperamide plasma concentrations. In the same study a CYP2C8 inhibitor, gemfibrozil, increased loperamide by approximately 2-fold. The combination of itraconazole and gemfibrozil resulted in a 4-fold increase in peak plasma levels of loperamide and a 13-fold increase in total plasma exposure. These increases were not associated with central nervous system (CNS) effects as measured by psychomotor tests (i.e. subjective drowsiness and the Digit Symbol Substitution Test). You can buy loperamide from pharmacies and supermarkets. It is also available on prescription for treating some bowel conditions. Other ingredients are: Gelatin, mannitol, aspartame, mint flavour and sodium hydrogen carbonate. What the medicine looks like The tablets contain loperamide hydrochloride, a substance that helps reduce diarrhoea by slowing down an overactive bowel. This allows water and salts that are usually lost in diarrhoea to be absorbed by the body. Before taking this medicine