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Carvalho, B. S. & Irizarry, R. A. A framework for oligonucleotide microarray preprocessing. Bioinformatics 26, 2363–2367 (2010). Prat, A. et al. Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer. Breast Cancer Res. 12, R68 (2010). Cibulskis, K. et al. Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples. Nat. Biotechnol. 31, 213–219 (2013).

While comparing the measurements of our population with those published of other nations and ethnicities, we found differences and similarities. The Nipple Areola Complex diameter was similar to Saudi Arabia and Turkey, but statistically different from Asian and Caucasian patients [3] [4] ( Table 8). In recent times, style icon, beauty mogul, and new mom Rihanna is lensed with her curves in focus for the September 2020 cover story. Other famous faces include Goop mogul Gwyneth Paltrow, the always-stunning Jennifer Aniston, as well as burgeoning supermodel, runway fixture, and J6 brand muse Anok Yai—who was featured in a sexy suiting story months earlier. Hailey Bieber, Demi Lovato, and everyone's favorite modeling duo Bella and Gigi Hadid are also on the list.Villarreal-Garza, C. et al. Real-world outcomes in young women with breast cancer treated with neoadjuvant chemotherapy. Breast Cancer Res. Treat. 157, 385–394 (2016). Big breasts might seem like a blessing to some. However, one buxom influencer finds her cumbersome chest to be a massive burden, as she’s allegedly forced to wear multiple bras at once to work out, among other inconveniences. The blond bombshell showed off her apparently problematic mammaries in a series of TikTok videos with millions of views. Establishing the standard Mexican Female Breast parameters from measurements obtained with this study will aid in obtaining a more predictable and aesthetically pleasing result in our population. Patients subject to breast augmentation, reduction, mastopexy and reconstructive breast surgery, will benefit from this data. Of note, when samples are grouped by age, HM patients analyzed did not present statistically significant difference in median TMB values between younger (<45 years old) and older patients, as occurs in tumors from Caucasian and Asian ancestry (TCGA and Japanese dataset) (Fig. 3b) (adjusted p< 0.05). Nor we observed a significant correlation between somatic mutation burden and age in our HM tumor series (Supplementary Fig. 4f). Deciphering mutational signatures

Rheinbay, E. et al. Recurrent and functional regulatory mutations in breast cancer. Nature 547, 55–60 (2017).

Hyman DM, et al. AKT Inhibition in Solid Tumors With AKT1 Mutations. Journal of Clinical Oncology 35, 2251-2259 (2017). Mexican patients diagnosed with primary breast cancer, without a second tumor and treated with adjuvant therapy at the Institute of Breast Diseases (FUCAM) from 2008–2012 were convenient collected. Tumor and adjacent non-tumoral tissue, as well as peripheral blood were obtained (EDTA Vacutainer tubes, BD, 6 ml) from each patient after informed consent was obtained. After macroscopic inspection by the pathologist, sections of tumor and normal tissue were frozen in liquid nitrogen and store at −80 °C until further processing. A section of the tissue was formalin fixed and embedded in paraffin (FFPE) to confirm pathological diagnosis, as well as to assess tumor cell content and grade by hematoxylin eosin (H&E) staining. Only samples with tumor content values >60% were further analyzed. Blood samples were centrifuged to separate and isolate buffy and plasma components. Additionally, one hundred consecutive FFPE specimens with adjuvant surgical resection (2012–2016) were convenient collected at Anatomic Pathology Department of FUCAM fulfilling the inclusion criteria described above. Tumor specimens were evaluated by a pathologist to determine their histotype and evaluate cellularity, to then macrodisected the most enriched area with tumoral cells (>60% of tumor cells). The clinical characteristics of the HM in-house-profiled samples are shown in Supplementary Data 1. The protocol was reviewed and approved by the Ethics and Research committees of the National Institute of Genomic Medicine and FUCAM Institute in Mexico City (CE2009/11). All the studies were conducted in accordance with the Declaration of Helsinki. Immunohistochemistry Rooney, M. S., Shukla, S. A., Wu, C. J., Getz, G. & Hacohen, N. Molecular and genetic properties of tumors associated with local immune cytolytic activity. Cell 160, 48–61 (2015). Plastic Surgery can be defined as the medical specialty where the artistic design and the surgical execution coexist in balance [2]. Therefore, to obtain optimal results, surgical techniques must be based on anthropometric measurements according to race, geographic location, and body mass index.

Kroenke, C. H. et al. Race and breast cancer survival by intrinsic subtype based on PAM50 gene expression. Breast Cancer Res. Treat. 144, 689–699 (2014).Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico Li, G. et al. Prevalence and spectrum of AKT1, PIK3CA, PTEN and TP53 somatic mutations in Chinese breast cancer patients. PLoS ONE 13, e0203495 (2018). Hannah said: “The only thing is I like to wear high-waisted things and on top of the boob thing, I am really short so I have no stomach.

Genomics Laboratory, Red de Apoyo a la Investigación, Universidad Nacional Autónoma de México-Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México City, México Introduce anal play with a Novice Plug, the perfect anal vibrator for newbies with a slim design, smooth silicone, and a remote control from up to 30 feet away." — A.W. After correlating the demographic characteristics (age, weight, BMI, height) with the anthropometric measurements, a positive medium and high correlation was found between weight/BMI and SNN:N, BV and BB. A Low correlation was found between weight/BMI and, ML:N and LBPL. We also found a correlation between age and SSN:N, LBPL, BV and BB. In contrast, no correlation was found between any age and ML:N, or height and any anthropometric measurement ( Table 5). Moreno-Estrada, A. et al. Human genetics. The genetics of Mexico recapitulates Native American substructure and affects biomedical traits. Science 344, 1280–1285 (2014). This represents a challenge for Plastic Surgeons in Mexico because an increased SNN:N distance in the context of a shorter height in the population, puts our patients at risk of ptosis regardless of the age.

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Comparing the values found in this study to the aesthetically ideal breast described by Malluci, we observe that our measurements fall far from what is considered ideal breast proportion [2] [7] ( Table 6). As mentioned previously this correlates with our findings in everyday practice, where we have detected an important prevalence of tuberous breasts. Yoshihara, K. et al. Inferring tumour purity and stromal and immune cell admixture from expression data. Nat. Commun. 4, 2612 (2013). Rose, A. S. et al. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics 34, 3755–3758 (2018). Avsar, D.K., Aygit, A.C., Benlier, E., Top, H. and Taskinalp, O. (2010) Anthropometric Breast Measurement: A Study of 385 Turkish Female Students. Aesthetic Surgery Journal/The American Society for Aesthetic Plastic Surgery, 30, 44-50. c protein visualization for AKT mutation was performed with RCSB PDB (rcsb.org) 77 for AKT E17K mutation (2UZS) with the NGL Viewer, and RCSB PDB 78. Mutational signatures