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A 2017 systematic review of 14 clinical trials, including the two described above, in 1,067 individuals with overweight or obesity showed that probiotics (mostly Lactobacillus administered at various doses for 3 weeks to 6 months) significantly decreased body weight and/or body fat in nine trials, had no effect in three trials, and increased body weight in two trials [ 61]. Another recent systematic review and meta-analysis of 15 RCTs in 957 individuals with overweight or obesity found that supplementation with various doses and strains of probiotics for 3 to 12 weeks resulted in larger reductions in body weight (by 0.6 kg), body mass index (by 0.27 kg/m 2), and fat percentage (by 0.6%) than placebo [ 62]. However, these effects were small and of questionable clinical significance. With clinically-researched live bacteria, combined with specifically-selected nutrients, ProVen products are designed for all life stages and individual needs.
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Keeping our children healthy is a primary focus for parents and here at ProVen, we understand how difficult it can be to get our kids to eat a healthy diet each day.Most published meta-analyses have shown that probiotics slightly reduce atopic dermatitis symptoms in infants and children. For example, a meta-analysis of 13 RCTs with a total of 1,070 participants age 18 years or younger found that probiotic treatment for 4 to 8 weeks of those with atopic eczema significantly reduced SCORing Atopic Dermatitis (SCORAD) values, indicating reduced symptom severity [ 15]. Subgroup analyses found probiotics had protective effects in children age 1 to 18 years (nine trials) but not in infants younger than 1 year (five trials). In addition, treatment with Lactobacillus, Lactobacillus fermentum, or a mixture of probiotic strains, significantly reduced SCORAD values in the children, whereas LGG and Lactobacillus plantarum had no effect.
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Another meta-analysis included eight randomized clinical trials with a total of 741 participants from birth to 36 months of age who were treated with Lactobacillus or Bifidobacterium for 4 to 24 weeks. The results also suggested that probiotics containing Lactobacillus might reduce atopic dermatitis symptoms in infants and toddlers, but those containing Bifidobacterium did not [ 16]. The treatment significantly improved symptoms in participants with moderate-to-severe forms of the disease but not in those with mild forms. A Cochrane Review of 39 RCTs of single probiotics and probiotic mixtures for the treatment of eczema in 2,599 participants age 1 to 55 years (most were children) found that probiotic treatment might slightly reduce SCORAD scores. However, the researchers concluded that the differences were not clinically significant and that the current evidence does not support the use of probiotics for eczema treatment [ 17].Freedman SB, Williamson-Urquhart S, Farion KJ, Gouin S, Willan AR, Poonai N, et al. Multicenter Trial of a Combination Probiotic for Children with Gastroenteritis. N Engl J Med 2018;379:2015-26. [ PubMed abstract] Gibson GR, Hutkins R, Sanders ME, Prescott SL, Reimer RA, Salminen SJ, et al. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol 2017;14:491-502. [ PubMed abstract] Silverman MA, Konnikova L, Gerber JS. Impact of antibiotics on necrotizing enterocolitis and antibiotic-associated diarrhea. Gastroenterol Clin North Am 2017;46:61-76. [ PubMed abstract] Caffarelli C, Cardinale F, Povesi-Dascola C, Dodi I, Mastrorilli V, Ricci G. Use of probiotics in pediatric infectious diseases. Expert Rev Anti Infect Ther 2015;13:1517-35. [ PubMed abstract] International Scientific Association for Probiotics and Prebiotics. Deciphering a probiotic label . 2017.
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